Ontology highlight
ABSTRACT:
SUBMITTER: Ghelli Luserna di Rora A
PROVIDER: S-EPMC7507691 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ghelli Luserna di Rorà Andrea A Cerchione Claudio C Martinelli Giovanni G Simonetti Giorgia G
Journal of hematology & oncology 20200921 1
The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has recently gained interest, and different DDR inhibitors have been developed. Among them, the most promising ones target the WEE1 kinase family, which has a crucial role in cell cycle regulation and DNA damage identification and repair in both nonmalignant and cancer cells. This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the ...[more]