Ontology highlight
ABSTRACT:
SUBMITTER: Shenoy A
PROVIDER: S-EPMC7507992 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Shenoy Anjana A Belugali Nataraj Nishanth N Perry Gili G Loayza Puch Fabricio F Nagel Remco R Marin Irina I Balint Nora N Bossel Noa N Pavlovsky Anya A Barshack Iris I Kaufman Bella B Agami Reuven R Yarden Yosef Y Dadiani Maya M Geiger Tamar T
Molecular systems biology 20200901 9
Tumor relapse as a consequence of chemotherapy resistance is a major clinical challenge in advanced stage breast tumors. To identify processes associated with poor clinical outcome, we took a mass spectrometry-based proteomic approach and analyzed a breast cancer cohort of 113 formalin-fixed paraffin-embedded samples. Proteomic profiling of matched tumors before and after chemotherapy, and tumor-adjacent normal tissue, all from the same patients, allowed us to define eight patterns of protein le ...[more]