Ontology highlight
ABSTRACT:
SUBMITTER: Gorman SD
PROVIDER: S-EPMC7508003 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Gorman Scott D SD Sahu Debashish D O'Rourke Kathleen F KF Boehr David D DD
Methods (San Diego, Calif.) 20180626
Solution-state NMR is an important tool for studying protein structure and function. The ability to probe methyl groups has substantially expanded the scope of proteins accessible by NMR spectroscopy, including facilitating study of proteins and complexes greater than 100 kDa in size. While the toolset for studying protein structure and dynamics by NMR continues to grow, a major rate-limiting step in these studies is the initial resonance assignments, especially for larger (>50 kDa) proteins. In ...[more]