Dataset Information

APOE ?4 and resting-state functional connectivity in racially/ethnically diverse older adults.

ABSTRACT: Introduction:Numerous neuroimaging studies demonstrated an association between the apolipoprotein E (APOE) ?4 allele and resting-state functional connectivity (rsFC) of regions within the default mode network (DMN), both in healthy populations and patients with AD. It remains unclear whether the APOE ?4 allele differentially affects the brain's functional network architecture across race/ethnicity. Methods:We investigated rsFC within DMN subsystems in 170 APOE ?4 carriers compared to 387 APOE ?4 non-carriers across three major racial/ethnic groups, including non-Hispanic Whites (n = 166), non-Hispanic Blacks (n = 185), and Hispanics (n = 206) from the Washington Heights-Inwood Columbia Aging Project. Results:Compared to APOE ?4 non-carriers, APOE ?4 carriers had lower rsFC in temporal DMN, but only in non-Hispanic Whites. Non-Hispanic Black and Hispanic APOE ?4 carriers had slightly higher or similar rsFC compared with non-Hispanic White APOE ?4 non-carriers. Discussion:These findings suggest that APOE ?4 modulates DMN rsFC differently in non-Hispanic Whites compared with non-Hispanic Blacks and Hispanics.

SUBMITTER: Turney IC

PROVIDER: S-EPMC7508460 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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APOE <i>ε</i>4 and resting-state functional connectivity in racially/ethnically diverse older adults.

Turney Indira C IC Chesebro Anthony G AG Rentería Miguel Arce MA Lao Patrick J PJ Beato Juliet M JM Schupf Nicole N Mayeux Richard R Manly Jennifer J JJ Brickman Adam M AM

Alzheimer's & dementia (Amsterdam, Netherlands) 20200922 1

<h4>Introduction</h4>Numerous neuroimaging studies demonstrated an association between the apolipoprotein E (APOE) <i>ε</i>4 allele and resting-state functional connectivity (rsFC) of regions within the default mode network (DMN), both in healthy populations and patients with AD. It remains unclear whether the APOE <i>ε</i>4 allele differentially affects the brain's functional network architecture across race/ethnicity.<h4>Methods</h4>We investigated rsFC within DMN subsystems in 170 APOE <i>ε</ ...[more]

PMID: 32999914

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Project description:IntroductionNon-standard visuomotor integration requires the interaction of large networks in the brain. Previous findings have shown that non-standard visuomotor performance is impaired in individuals with specific dementia risk factors (family history of dementia and presence of the APOE ε4 allele) in advance of any cognitive impairments. These findings suggest that visuomotor impairments are associated with early dementia-related brain changes. The current study examined the underlying resting state functional connectivity (RSFC) associated with impaired non-standard visuomotor performance, as well as the impacts of dementia family history, sex, and APOE status.MethodsCognitively healthy older adults (n = 48) were tested on four visuomotor tasks where reach and gaze were increasingly spatially dissociated. Participants who had a family history of dementia or the APOE ε4 allele were considered to be at an increased risk for AD. To quantify RSFC within networks of interest, an EPI sequence sensitive to BOLD contrast was collected. The networks of interest were the default mode network (DMN), somatomotor network (SMN), dorsal attention network (DAN), ventral attention network (VAN), and frontoparietal control network (FPN).ResultsIndividuals with the ε4 allele showed abnormalities in RSFC between posterior DMN nodes that predicted poorer non-standard visuomotor performance. Specifically, multiple linear regression analyses revealed lower RSFC between the precuneus/posterior cingulate cortex and the left inferior parietal lobule as well as the left parahippocampal cortex. Presence of the APOE ε4 allele also modified the relationship between mean DAN RSFC and visuomotor control, where lower mean RSFC in the DAN predicted worse non-standard visuomotor performance only in APOE ε4 carriers. There were otherwise no effects of family history, APOE ε4 status, or sex on the relationship between RSFC and visuomotor performance for any of the other resting networks.ConclusionThe preliminary findings provide insight into the impact of APOE ε4-related genetic risk on neural networks underlying complex visuomotor transformations, and demonstrate that the non-standard visuomotor task paradigm discussed in this study may be used as a non-invasive, easily accessible assessment tool for dementia risk.

Dataset Information

APOE ?4 and resting-state functional connectivity in racially/ethnically diverse older adults.

Publications

APOE <i>ε</i>4 and resting-state functional connectivity in racially/ethnically diverse older adults.

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