APOE ?4 and resting-state functional connectivity in racially/ethnically diverse older adults.
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ABSTRACT:
SUBMITTER: Turney IC
PROVIDER: S-EPMC7508460 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
APOE <i>ε</i>4 and resting-state functional connectivity in racially/ethnically diverse older adults.
Turney Indira C IC Chesebro Anthony G AG Rentería Miguel Arce MA Lao Patrick J PJ Beato Juliet M JM Schupf Nicole N Mayeux Richard R Manly Jennifer J JJ Brickman Adam M AM
Alzheimer's & dementia (Amsterdam, Netherlands) 20200922 1
<h4>Introduction</h4>Numerous neuroimaging studies demonstrated an association between the apolipoprotein E (APOE) <i>ε</i>4 allele and resting-state functional connectivity (rsFC) of regions within the default mode network (DMN), both in healthy populations and patients with AD. It remains unclear whether the APOE <i>ε</i>4 allele differentially affects the brain's functional network architecture across race/ethnicity.<h4>Methods</h4>We investigated rsFC within DMN subsystems in 170 APOE <i>ε</ ...[more]
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