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Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China.


ABSTRACT: A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in A. fumigatus from soil samples.

SUBMITTER: Cao D 

PROVIDER: S-EPMC7508624 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental <i>Aspergillus fumigatus</i> Isolates from China.

Cao Duantao D   Wu Ruilin R   Dong Suxia S   Wang Feiyan F   Ju Chao C   Yu Sumei S   Xu Shiji S   Fang Hua H   Yu Yunlong Y  

Antimicrobial agents and chemotherapy 20200921 10


A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) <i>Aspergillus fumigatus</i> and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in <i>A. fumigatus</i>  ...[more]

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