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Dynamic and subtype-specific interactions between tumour burden and prognosis in breast cancer.


ABSTRACT: We investigated the relationship between the prognostic importance of anatomic tumour burden and subtypes of breast cancer using data from the Korean Breast Cancer Registry Database. In HR+/HER2+ and HR-/HER2-tumours, an increase in T stage profoundly increased the hazard of death, while the presence of lymph node metastasis was more important in HR+/HER2+ and HR-/HER2+ tumours among 131,178 patients with stage I-III breast cancer. The patterns of increasing mortality risk and tumour growth (per centimetre) and metastatic nodes (per node) were examined in 67,038 patients with a tumour diameter???7 cm and??3 or 4 nodes. The interactions between the prognostic significance of anatomic tumour burden and subtypes were significant. The prognostic relevance of the anatomic tumour burden was non-linear and highly dependent on the subtypes of breast cancer.

SUBMITTER: Lee SB 

PROVIDER: S-EPMC7508816 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Dynamic and subtype-specific interactions between tumour burden and prognosis in breast cancer.

Lee S B SB   Kim H-K HK   Choi Y Y   Ju Y W YW   Lee H-B HB   Han W W   Noh D-Y DY   Son B H BH   Ahn S H SH   Kim K S KS   Nam S J SJ   Kim E-K EK   Park H Y HY   Park W-C WC   Lee J W JW   Moon H-G HG  

Scientific reports 20200922 1


We investigated the relationship between the prognostic importance of anatomic tumour burden and subtypes of breast cancer using data from the Korean Breast Cancer Registry Database. In HR+/HER2+ and HR-/HER2-tumours, an increase in T stage profoundly increased the hazard of death, while the presence of lymph node metastasis was more important in HR+/HER2+ and HR-/HER2+ tumours among 131,178 patients with stage I-III breast cancer. The patterns of increasing mortality risk and tumour growth (per  ...[more]

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