Ontology highlight
ABSTRACT:
SUBMITTER: Murray KA
PROVIDER: S-EPMC7509910 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Murray Kathryn A KA Tomás Ruben M F RMF Gibson Matthew I MI
ACS applied bio materials 20200818 9
Mesenchymal stromal (stem) cells have potential in regenerative medicine and modulating the immune system. To deliver any cell-based therapy to the patient, it must be cryopreserved, most commonly in DMSO, which impacts cell function and causes clinical side effects. Here we report the use of a synthetically scalable polyampholyte to rescue the cryopreservation of mesenchymal stromal cells in low [DMSO] cryopreservation. Flow cytometry showed retention of key markers of multipotency comparable t ...[more]