Browse
Submit Data
Databases
API
Help

Dataset Information

28 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Application of carbon nanomaterials in human virus detection

ABSTRACT: Human-pathogenic viruses are still a chief reason for illness and death on the globe, as epitomized by the COVID-19 pandemic instigated by a coronavirus in 2020. Multiple novel sensors have been invented because diseases must be detected and diagnosed as early as possible, and recognition methods have to be carried out with minimal invasivity. Sensors have been particularly developed focusing on miniaturization by the use of nanomaterials for fabricating nanosensors. The nano-sized nature of nanomaterials and their exclusive optical, electronical, magnetical, and mechanical attributes can enhance patient care through the use of sensors with minimal invasivity and extreme sensitivity. Amongst the nanomaterials utilized for fabricating nano-sensors, carbon-based nanomaterials are promising as these sensors respond better to signals in various sensing settings. This review provides an overview of the recent developments in carbon nanomaterial-based biosensors for viral recognition based on the biomarkers that arise from the infection, the nucleic acids from the viruses, and the entire virus. The role of carbon nanomaterials is highlighted by the improvement of sensor and recognition functionality. The Dengue virus, Ebola virus, Hepatits virus, human immunodeficiency virus (HIV), influenza virus, Zika virus and Adenovirus are the virus types reviewed to illustrate the implementation of the techniques. Finally, the drawbacks and advantages of carbon nanomaterial-based biosensors for viral recognition are identified and discussed.

SUBMITTER: Ehtesabi H

PROVIDER: S-EPMC7509950 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

The production and application of carbon nanomaterials from high alkali silicate herbaceous biomass.

Project description:Herein, value-added materials such as activated carbon and carbon nanotubes were synthesized from low-value Miscanthus?×?giganteus lignocellulosic biomass. A significant drawback of using Miscanthus in an energy application is the melting during the combustion due to its high alkali silicate content. An application of an alternative approach was proposed herein for synthesis of activated carbon from Miscanthus?×?giganteus, where the produced activated carbon possessed a high surface area and pore volume of 0.92?cm3.g-1 after two activation steps using phosphoric acid and potassium hydroxide. The SBET of the raw biomass, after first activation and second activation methods showed 17, 1142 and 1368?m2.g-1, respectively. Transforming this otherwise waste material into a useful product where its material properties can be utilized is an example of promoting the circular economy by valorising waste lignocellulosic biomass to widely sought-after high surface area activated carbon and subsequently, unconventional multi-walled carbon nanotubes. This was achieved when the activated carbon produced was mixed with nitrogen-based material and iron precursor, where it produced hydrophilic multi-wall carbon nanotubes with a contact angle of ??=?9.88°, compared to the raw biomass. synthesised materials were tested in heavy metal removal tests using a lead solution, where the maximum lead absorption was observed for sample AC-K, with a 90% removal capacity after the first hour of testing. The synthesis of these up-cycled materials can have potential opportunities in the areas of wastewater treatment or other activated carbon/carbon nanotube end uses with a rapid cycle time.

| S-EPMC7018825 | biostudies-literature

Improvement of Commercially Valuable Traits of Industrial Crops by Application of Carbon-based Nanomaterials.

Project description:Carbon-based nanomaterials (CBNs) have great potential as a powerful tool to improve plant productivity. Here, we investigated the biological effects of graphene and carbon nanotubes (CNTs) on fiber-producing species (cotton, Gossypium hirsutum) and ornamental species (vinca, Catharanthus roseus). The exposure of seeds to CNTs or graphene led to the activation of early seed germination in Catharanthus and overall higher germination in cotton and Catharanthus seeds. The application of CBNs resulted in higher root and shoot growth of young seedlings of both tested species. Cultivation of Catharanthus plants in soil supplemented with CBNs resulted in the stimulation of plant reproductive system by inducing early flower development along with higher flower production. Catharanthus plants cultivated in CNTs or graphene supplemented soil accelerated total flower production by 37 and 58%, respectively. Additionally, CBNs reduced the toxic effects caused by NaCl. Long-term application of CBNs to crops cultivated under salt stress conditions improved the desired phenotypical traits of Catharanthus (higher flower number and leaf number) and cotton (increased fiber biomass) compared to untreated plants of both species cultivated at the same stress condition. The drought stress experiments revealed that introduction of CBNs to matured Catharanthus plant increased the plant survival with no symptoms of leaf wilting as compared to untreated Catharanthus growing in water deficit conditions.

| S-EPMC6920410 | biostudies-literature

Interaction studies of carbon nanomaterials and plasma activated carbon nanomaterials solution with telomere binding protein.

Project description:Most cancer cells have telomerase activity because they can express the human telomerase reverse transcriptase (hTERT) gene. Therefore, the inhibition of the hTERT expression can play an important role in controlling cancer cell proliferation. Our current study aims to inhibit hTERT expression. For this, we synthesized graphene oxide (GO) and a functionalized multiwall carbon nanotube (f-MWCNT), latter treated them with cold atmospheric pressure plasma for further analysis of the hTERT expression. The inhibition of hTERT expression by GO, f-MWCNT, plasma activated GO solution (PGOS), and plasma activated f-MWCNT solution (PCNTS), was studied using two lung cancer cell lines, A549 and H460. The hTERT experimental results revealed that GO and PGOS sufficiently decreased the hTERT concentration, while f-MWCNT and PCNTS were unable to inhibit the hTERT concentration. Therefore, to understand the inhibition mechanism of hTERT, we studied the binding properties of GO and PGOS with telomere binding protein (AtTRB2). The interaction studies were carried out using circular dichroism, fluorescence, 1H-15N NMR spectroscopy, and size-exclusion chromatography (SEC) binding assay. We also used docking simulation to have an better understanding of the interactions between GO nanosheets and AtTRB2 protein. Our results may provide new insights that can benefit in biomedical treatments.

| S-EPMC5454022 | biostudies-literature

Near-Real Time Measurement of Carbonaceous Aerosol Using Microplasma Spectroscopy: Application to Measurement of Carbon Nanomaterials.

Project description:A sensitive, field-portable microplasma spectroscopy method has been developed for real-time measurement of carbon nanomaterials. The method involves microconcentration of aerosol on a microelectrode tip for subsequent analysis for atomic carbon using laser-induced breakdown spectroscopy (LIBS) or spark emission spectroscopy (SES). The spark-induced microplasma was characterized by measuring the excitation temperature (15,000 - 35,000 K), electron density (1.0 × 1017 - 2.2 × 1017 cm-3), and spectral responses as functions of time and interelectrode distance. The system was calibrated and detection limits were determined for total atomic carbon (TAC) using a carbon emission line at 247.856 nm (C I) for various carbonaceous materials including sucrose, EDTA, caffeine, sodium carbonate, carbon black, and carbon nanotubes. The limit of detection for total atomic carbon was 1.61 ng, equivalent to 238 ng m-3 when sampling at 1.5 L min-1 for 5 min. To improve the selectivity for carbon nanomaterials, which consist of elemental carbon (EC), the cathode was heated to 300 °C to reduce the contribution of organic carbon to the total atomic carbon. Measurements of carbon nanotube aerosol at elevated electrode temperature showed improved selectivity to elemental carbon and compared well with the measurements from thermal optical method (NIOSH Method 5040). The study shows that the SES method to be an excellent candidate for development as a low-cost, hand-portable, real-time instrument for measurement of carbonaceous aerosols and nanomaterials.

| S-EPMC5476210 | biostudies-literature

CIP anaerobic removal with carbon nanomaterials

Project description:Ciprofloxacin anaerobic removal with carbon nanomaterials

| PRJEB43083 | ENA

Carbon Nanomaterials as Antibacterial Colloids.

Project description:Carbon nanomaterials like graphene, carbon nanotubes, fullerenes and the various forms of diamond have attracted great attention for their vast potential regarding applications in electrical engineering and as biomaterials. The study of the antibacterial properties of carbon nanomaterials provides fundamental information on the possible toxicity and environmental impact of these materials. Furthermore, as a result of the increasing prevalence of resistant bacteria strains, the development of novel antibacterial materials is of great importance. This article reviews current research efforts on characterizing the antibacterial activity of carbon nanomaterials from the perspective of colloid and interface science. Building on these fundamental findings, recent functionalization strategies for enhancing the antibacterial effect of carbon nanomaterials are described. The review concludes with a comprehensive outlook that summarizes the most important discoveries and trends regarding antibacterial carbon nanomaterials.

| S-EPMC5509023 | biostudies-other

Ice Nucleation Properties of Oxidized Carbon Nanomaterials.

Project description:Heterogeneous ice nucleation is an important process in many fields, particularly atmospheric science, but is still poorly understood. All known inorganic ice nucleating particles are relatively large in size and tend to be hydrophilic. Hence it is not obvious that carbon nanomaterials should nucleate ice. However, in this paper we show that four different readily water-dispersible carbon nanomaterials are capable of nucleating ice. The tested materials were carboxylated graphene nanoflakes, graphene oxide, oxidized single walled carbon nanotubes and oxidized multiwalled carbon nanotubes. The carboxylated graphene nanoflakes have a diameter of ?30 nm and are among the smallest entities observed so far to nucleate ice. Overall, carbon nanotubes were found to nucleate ice more efficiently than flat graphene species, and less oxidized materials nucleated ice more efficiently than more oxidized species. These well-defined carbon nanomaterials may pave the way to bridging the gap between experimental and computational studies of ice nucleation.

| S-EPMC4550106 | biostudies-literature

Recent advances in carbon monoxide-releasing nanomaterials.

Project description:As an endogenous signaling molecule, carbon monoxide (CO) has emerged as an increasingly promising option regarding as gas therapy due to its positive pharmacological effects in various diseases. Owing to the gaseous nature and potential toxicity, it is particularly important to modulate the CO release dosages and targeted locations to elucidate the biological mechanisms of CO and facilitate its clinical applications. Based on these, diverse CO-releasing molecules (CORMs) have been developed for controlled release of CO in biological systems. However, practical applications of these CORMs are limited by several disadvantages including low stability, poor solubility, weak releasing controllability, random diffusion, and potential toxicity. In light of rapid developments and diverse advantages of nanomedicine, abundant nanomaterials releasing CO in controlled ways have been developed for therapeutic purposes across various diseases. Due to their nanoscale sizes, diversified compositions and modified surfaces, vast CO-releasing nanomaterials (CORNMs) have been constructed and exhibited controlled CO release in specific locations under various stimuli with better pharmacokinetics and pharmacodynamics. In this review, we present the recent progress in CORNMs according to their compositions. Following a concise introduction to CO therapy, CORMs and CORNMs, the representative research progress of CORNMs constructed from organic nanostructures, hybrid nanomaterials, inorganic nanomaterials, and nanocomposites is elaborated. The basic properties of these CORNMs, such as active components, CO releasing mechanisms, detection methods, and therapeutic applications, are discussed in detail and listed in a table. Finally, we explore and discuss the prospects and challenges associated with utilizing nanomaterials for biological CO release.

| S-EPMC10955104 | biostudies-literature

Improved Electrochemical Hydrogen Peroxide Detection Using a Nickel(II) Phthalimide-Substituted Porphyrazine Combined with Various Carbon Nanomaterials.

Project description:A metal-free porphyrazine derivative with peripheral phthalimide substituents was metallated with a nickel(II) ion. The purity of the nickel macrocycle was confirmed using HPLC, and characterized by MS, UV-VIS, and 1D (1H, 13C) and 2D (1H-13C HSQC, 1H-13C HMBC, 1H-1H COSY) NMR techniques. The novel porphyrazine was combined with various carbon nanomaterials, such as carbon nanotubes-single walled (SWCNTs) and multi-walled (MWCNTs), and electrochemically reduced graphene oxide (rGO), to create hybrid electroactive electrode materials. The carbon nanomaterials' effect on the electrocatalytic properties of nickel(II) cations was compared. As a result, an extensive electrochemical characterization of the synthesized metallated porphyrazine derivative on various carbon nanostructures was carried out using cyclic voltammetry (CV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS). An electrode modified with carbon nanomaterials GC/MWCNTs, GC/SWCNTs, or GC/rGO, respectively, was shown to have a lower overpotential than a bare glassy carbon electrode (GC), allowing for the measurement of hydrogen peroxide in neutral conditions (pH 7.4). It was shown that among the tested carbon nanomaterials, the modified electrode GC/MWCNTs/Pz3 exhibited the best electrocatalytic properties in the direction of hydrogen peroxide oxidation/reduction. The prepared sensor was determined to enable a linear response to H2O2 in concentrations ranging between 20-1200 µM with the detection limit of 18.57 µM and sensitivity of 14.18 µA mM-1 cm-2. As a result of this research, the sensors produced here may find use in biomedical and environmental applications.

| S-EPMC10005363 | biostudies-literature

Application of Zero-Dimensional Nanomaterials in Biosensing.

Project description:Zero-dimensional (0D) nanomaterials, including graphene quantum dots (GQDs), carbon quantum dots (CQDs), fullerenes, inorganic quantum dots (QDs), magnetic nanoparticles (MNPs), noble metal nanoparticles, upconversion nanoparticles (UCNPs) and polymer dots (Pdots), have attracted extensive research interest in the field of biosensing in recent years. Benefiting from the ultra-small size, quantum confinement effect, excellent physical and chemical properties and good biocompatibility, 0D nanomaterials have shown great potential in ion detection, biomolecular recognition, disease diagnosis and pathogen detection. Here we first introduce the structures and properties of different 0D nanomaterials. On this basis, recent progress and application examples of 0D nanomaterials in the field of biosensing are discussed. In the last part, we summarize the research status of 0D nanomaterials in the field of biosensing and anticipate the development prospects and future challenges in this field.

| S-EPMC7182656 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data