High-dose post-transplant cyclophosphamide impairs γδ T-cell reconstitution after haploidentical haematopoietic stem cell transplantation using low-dose antithymocyte globulin and peripheral blood stem cell graft.

ABSTRACT:

Objectives

Haploidentical haematopoietic cell transplantation (Haplo-HCT) using peripheral blood stem cell (PBSC) grafts and post-transplant cyclophosphamide (PTCy) is being increasingly used; however, data on immunological reconstitution (IR) are still scarce.

Methods

This retrospective study evaluated T-cell immunological reconstitution in 106 adult patients who underwent allogeneic haematopoietic cell transplantation for haematologic malignancies between 2013 and 2016.

Results

At D30, while conventional T cells reached similar median counts in Haplo-HCT recipients (n = 19) and controls (n = 87), γδ and Vδ2⁺ T-cell median counts were significantly lower in Haplo-HCT recipients and it persists at least until D360 for Vδ2⁺ T cells.

SUBMITTER: Stocker N 

PROVIDER: S-EPMC7511259 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature