Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura R
PROVIDER: S-EPMC7511394 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Communications biology 20200923 1
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought to have multifactorial pathogenesis. To understand the genetics of sporadic ALS, we conducted a genome-wide association study using 1,173 sporadic ALS cases and 8,925 controls in a Japanese population. A combined meta-analysis of our Japanese cohort with individuals of European ancestry revealed a significant associa ...[more]