Ontology highlight
ABSTRACT:
SUBMITTER: Oh J
PROVIDER: S-EPMC7511948 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Oh J J Matkovich S J SJ Riek A E AE Bindom S M SM Shao J S JS Head R D RD Barve R A RA Sands M S MS Carmeliet G G Osei-Owusu P P Knutsen R H RH Zhang H H Blumer K J KJ Nichols C G CG Mecham R P RP Baldán Á Á Benitez B A BA Sequeira-Lopez M L ML Gomez R A RA Bernal-Mizrachi C C
Nature communications 20200923 1
Myeloid cells are known mediators of hypertension, but their role in initiating renin-induced hypertension has not been studied. Vitamin D deficiency causes pro-inflammatory macrophage infiltration in metabolic tissues and is linked to renin-mediated hypertension. We tested the hypothesis that impaired vitamin D signaling in macrophages causes hypertension using conditional knockout of the myeloid vitamin D receptor in mice (KODMAC). These mice develop renin-dependent hypertension due to macroph ...[more]