Ontology highlight
ABSTRACT:
SUBMITTER: Sekiba K
PROVIDER: S-EPMC7512021 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Sekiba Kazuma K Otsuka Motoyuki M Seimiya Takahiro T Tanaka Eri E Funato Kazuyoshi K Miyakawa Yu Y Koike Kazuhiko K
Scientific reports 20200923 1
MICA/B proteins are expressed on the surface of various types of stressed cells, including cancer cells. Cytotoxic lymphocytes expressing natural killer group 2D (NKG2D) receptor recognize MICA/B and eliminate the cells. However, cancer cells evade such immune recognition by inducing proteolytic shedding of MICA/B proteins. Therefore, preventing the shedding of MICA/B proteins could enhance antitumor immunity. Here, by screening a protease inhibitor library, we found that the fatty-acid amide hy ...[more]