Action of a minimal contractile bactericidal nanomachine.
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ABSTRACT:
SUBMITTER: Ge P
PROVIDER: S-EPMC7513463 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Action of a minimal contractile bactericidal nanomachine.
Ge Peng P Scholl Dean D Prokhorov Nikolai S NS Avaylon Jaycob J Shneider Mikhail M MM Browning Christopher C Buth Sergey A SA Plattner Michel M Chakraborty Urmi U Ding Ke K Leiman Petr G PG Miller Jeff F JF Zhou Z Hong ZH
Nature 20200415 7805
R-type bacteriocins are minimal contractile nanomachines that hold promise as precision antibiotics<sup>1-4</sup>. Each bactericidal complex uses a collar to bridge a hollow tube with a contractile sheath loaded in a metastable state by a baseplate scaffold<sup>1,2</sup>. Fine-tuning of such nucleic acid-free protein machines for precision medicine calls for an atomic description of the entire complex and contraction mechanism, which is not available from baseplate structures of the (DNA-contain ...[more]
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