Effects of proton pump inhibitor use on the esophageal microbial community.

ABSTRACT: BACKGROUND:Changes in the esophageal microbiome correlate with esophageal disease, but the effects of proton pump inhibitor (PPI) drugs are incompletely characterized. Our objective was to identify the effects of PPI use on the microbial community of the esophagus. METHODS:Mucosal biopsies of the distal esophagus were analyzed using a customized esophageal microbiome qPCR panel array (EMB). Patient demographics, use of PPIs, duration of use and dose were recorded. RESULTS:Fifty-eight patients were included. Mean age was 60.5?years. Ninety percent (52/58) of patients were on PPIs. Mean dose was 42.7?mg. Mean duration of use was 2.5?years. The use of PPIs led to a significant difference in absolute levels of only one organism, Actinomyces, in the entire array (p?

SUBMITTER: Tasnim S 

PROVIDER: S-EPMC7513526 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature