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Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.

ABSTRACT: Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGF?) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are closely related to the proliferation of endothelial cells, the recruitment of pericytes to blood vessels, and functional differentiation during embryonic vascular development. The pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular cells. Indeed, mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous malformation. Many studies have shown that ALK1 is closely related to the development of cerebral aneurysms, arteriovenous malformations, and cerebral atherosclerosis. In this review, we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis, and we discuss its relationship to functional dysregulation in cerebrovascular diseases. This review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis, treatment, and prevention.

SUBMITTER: Hong JM

PROVIDER: S-EPMC7513971 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.

Hong Jun-Mou JM Hu Yi-Da YD Chai Xiao-Qing XQ Tang Chao-Liang CL

Neural regeneration research 20201001 10

Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are closely related to the proliferation of endothelial cells, the recruitment of pericytes to blood vessels, and functional differentiation during embryonic vascular development. The pathophysiology of many cerebrovascular diseases is today understood as ...[more]

PMID: 32246621

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Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.

Publications

Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.

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