Ontology highlight
ABSTRACT:
SUBMITTER: Jin SW
PROVIDER: S-EPMC7515180 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Jin Steven W SW Mwimanzi Francis M FM Mann Jaclyn K JK Bwana Mwebesa Bosco MB Lee Guinevere Q GQ Brumme Chanson J CJ Hunt Peter W PW Martin Jeff N JN Bangsberg David R DR Ndung'u Thumbi T Brumme Zabrina L ZL Brockman Mark A MA
PLoS pathogens 20200914 9
HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited. Here, we quantify SERINC3 and SERINC5 internalization function for 339 Nef clones, representing the major pandemic HIV-1 group M subtypes A, B, C and D. We describe distinct subtype-associated hierarchies for Nef-mediated internalization of SERINC5, for which subtype B clones display the highest activities o ...[more]