Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B₁₀₀-Reactive CD4⁺ T-Regulatory Cells.

ABSTRACT:

Background

Throughout the inflammatory response that accompanies atherosclerosis, autoreactive CD4⁺ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein B₁₀₀ (apoB), the core protein of low-density lipoprotein, is an autoantigen that drives the generation of pathogenic T-helper type 1 (T_H1) cells with proinflammatory cytokine secretion. Clinical data suggest the existence of apoB-specific CD4⁺ T cells with an atheroprotective, regulatory T cell (T_reg) phenotype in healthy individuals. Yet, the function of apoB-reactive T_regs and their relationship with pathogenic T_H1 cells remain unknown.

Methods

To interrogate the function of autoreactive CD4⁺ T cells in atherosclerosi

SUBMITTER: Wolf D 

PROVIDER: S-EPMC7515473 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature