Ontology highlight
ABSTRACT:
SUBMITTER: Kalwak K
PROVIDER: S-EPMC7515850 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kalwak Krzysztof K Mielcarek Monika M Patrick Katharine K Styczynski Jan J Bader Peter P Corbacioglu Selim S Burkhardt Birgit B Sykora Karl Walter KW Drabko Katarzyna K Gozdzik Jolanta J Fagioli Franca F Greil Johann J Gruhn Bernd B Beier Rita R Locatelli Franco F Müller Ingo I Schlegel Paul Gerhardt PG Sedlacek Petr P Stachel Klaus Daniel KD Hemmelmann Claudia C Möller Ann-Kristin AK Baumgart Joachim J Vora Ajay A
Bone marrow transplantation 20200320 10
Treosulfan-based conditioning prior to allogeneic transplantation has been shown to have myeloablative, immunosuppressive, and antineoplastic effects associated with reduced non-relapse mortality (NRM) in adults. Therefore, we prospectively evaluated the safety and efficacy of treosulfan-based conditioning in children with hematological malignancies in this phase II trial. Overall, 65 children with acute lymphoblastic leukemia (35.4%), acute myeloid leukemia (44.6%), myelodysplastic syndrome (15 ...[more]