1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats.
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ABSTRACT:
SUBMITTER: Watanabe A
PROVIDER: S-EPMC7515885 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats.
Watanabe Ayako A Kadota Yoshihiro Y Kamio Rina R Tochio Takumi T Endo Akihito A Shimomura Yoshiharu Y Kitaura Yasuyuki Y
Scientific reports 20200924 1
The fructooligosaccharide 1-kestose cannot be hydrolyzed by gastrointestinal enzymes, and is instead fermented by the gut microbiota. Previous studies suggest that 1-kestose promotes increases in butyrate concentrations in vitro and in the ceca of rats. Low levels of butyrate-producing microbiota are frequently observed in the gut of patients and experimental animals with type 2 diabetes (T2D). However, little is known about the role of 1-kestose in increasing the butyrate-producing microbiota a ...[more]
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