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Serum CA72-4 is specifically elevated in gout patients and predicts flares.

ABSTRACT: OBJECTIVES:Serum CA72-4 levels are elevated in some gout patients but this has not been comprehensively described. The present study profiled serum CA72-4 expression in gout patients and verified the hypothesis that CA72-4 is a predictor of future flares in a prospective gout cohort. METHODS:To profile CA72-4 expression, a cross-sectional study was conducted in subjects with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) and healthy controls. A prospective gout cohort study was initiated to test the value of CA72-4 for predicting gout flares. During a 6-month follow-up, gout flares, CA72-4 levels and other gout-related clinical variables were observed at 1, 3 and 6?months. RESULTS:CA72-4 was highly expressed in patients with gouty arthritis [median (interquartile range) 4.55 (1.56, 32.64) U/ml] compared with hyperuricaemia patients [1.47 (0.87, 3.29) U/ml], healthy subjects [1.59 (0.99, 3.39) U/ml] and other arthritis patients [septic arthritis, 1.38 (0.99, 2.66) U/ml; RA, 1.58 (0.95, 3.37) U/ml; SpA, 1.56 (0.98, 2.85) U/ml; OA, 1.54 (0.94, 3.34) U/ml; P?6.9?U/ml) was the strongest predictor of gout flares (hazard ratio?=?3.889). Prophylactic colchicine was effective, especially for patients with high CA72-4 levels (P?=?0.014). CONCLUSION:CA72-4 levels were upregulated in gout patients who experienced frequent flares and CA72-4 was a useful biomarker to predict future flares.

SUBMITTER: Bai X

PROVIDER: S-EPMC7516098 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Serum CA72-4 is specifically elevated in gout patients and predicts flares.

Bai Xueshan X Sun Mingshu M He Yuwei Y Liu Ruhua R Cui Lingling L Wang Can C Wan Fang F Wang Ming M Li Xinde X Li Hailong H Wu Xinjiang X Li Changgui C

Rheumatology (Oxford, England) 20201001 10

<h4>Objectives</h4>Serum CA72-4 levels are elevated in some gout patients but this has not been comprehensively described. The present study profiled serum CA72-4 expression in gout patients and verified the hypothesis that CA72-4 is a predictor of future flares in a prospective gout cohort.<h4>Methods</h4>To profile CA72-4 expression, a cross-sectional study was conducted in subjects with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) an ...[more]

PMID: 32087013

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Serum CA72-4 is specifically elevated in gout patients and predicts flares.

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Serum CA72-4 is specifically elevated in gout patients and predicts flares.

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