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Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition.

ABSTRACT: Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of atypical Stress Granules, independently of fatty acid synthase inhibition, characterized by high internal mobility and rapid turnover.

SUBMITTER: Amen T

PROVIDER: S-EPMC7516299 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition.

Amen Triana T Kaganovich Daniel D

iScience 20200910 10

Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of atypical Stress Granules, independently of fatty acid sy ...[more]

PMID: 33083719

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