Ontology highlight
ABSTRACT:
SUBMITTER: Amen T
PROVIDER: S-EPMC7516299 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Amen Triana T Kaganovich Daniel D
iScience 20200910 10
Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of atypical Stress Granules, independently of fatty acid sy ...[more]