Ontology highlight
ABSTRACT:
SUBMITTER: Haskali MB
PROVIDER: S-EPMC7517343 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Haskali Mohammad B MB Farnsworth Ashleigh L AL Roselt Peter D PD Hutton Craig A CA
RSC medicinal chemistry 20200707 8
Indirect radiolabelling has for a long time been the mainstay strategy for radiofluorination of biomolecules. Acylation of biomolecules through the use of an <sup>18</sup>F-labelled activated ester is a standard method for indirect radiolabelling. However, the preparation of <sup>18</sup>F-labelled activated esters is typically a complex and multistep procedure. Herein, we describe the use of 4-nitrophenyl (PNP) activated esters to rapidly prepare <sup>18</sup>F-labelled acylation synthons in on ...[more]