Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs.
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ABSTRACT:
SUBMITTER: Pilla R
PROVIDER: S-EPMC7517498 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs.
Pilla Rachel R Gaschen Frederic P FP Barr James W JW Olson Erin E Honneffer Julia J Guard Blake C BC Blake Amanda B AB Villanueva Dean D Khattab Mohammad R MR AlShawaqfeh Mustafa K MK Lidbury Jonathan A JA Steiner Jörg M JM Suchodolski Jan S JS
Journal of veterinary internal medicine 20200828 5
<h4>Background</h4>Metronidazole has a substantial impact on the gut microbiome. However, the recovery of the microbiome after discontinuation of administration, and the metabolic consequences of such alterations have not been investigated to date.<h4>Objectives</h4>To describe the impact of 14-day metronidazole administration, alone or in combination with a hydrolyzed protein diet, on fecal microbiome, metabolome, bile acids (BAs), and lactate production, and on serum metabolome in healthy dogs ...[more]
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