Exploring the genetic relationship between hearing impairment and Alzheimer's disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell BL
PROVIDER: S-EPMC7517507 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Exploring the genetic relationship between hearing impairment and Alzheimer's disease.
Mitchell Brittany L BL Thorp Jackson G JG Evans David M DM Nyholt Dale R DR Martin Nicholas G NG Lupton Michelle K MK
Alzheimer's & dementia (Amsterdam, Netherlands) 20200925 1
<h4>Introduction</h4>Hearing loss has been identified as the potentially largest modifiable risk factor for Alzheimer's disease (AD), estimated to account for a similar increase in AD risk as the apolipoprotein E (<i>APOE</i>) gene.<h4>Methods</h4>We investigated the genetic relationship between hearing loss and AD, and sought evidence for a causal relationship.<h4>Results</h4>We found a significant genetic overlap between hearing impairment and AD and a polygenic risk score for AD was able to s ...[more]
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