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Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study.


ABSTRACT:

Background

With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants.

Methods

We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their development with an historical group of infants born by non-instrumental vaginal delivery.

Results

Infants born by prelabour caesarean section were compared with a group of vaginally born infants. Follow-up assessments were performed at 4 and 12 months. Prelabour caesarean infants (n = 66) had significantly lower Ages and Stages Questionnaire, second edition (ASQ-II) scores in all domains (communication, gross motor, fine motor, problem solving and personal-social) at 4 months of age with an adjusted mean difference (95% CI) of - 20.7 (- 28.7 to - 12.6) in ASQ-II total score as compared to vaginally born infants (n = 352). These differences remained for gross-motor skills at the 12 month assessment, adjusted mean difference (95% CI) -4.7 (- 8.8 to - 0.7), n = 62 and 336.

Conclusions

Adverse neurodevelopmental outcomes in infants born by prelabour caesarean section may be apparent already a few months after birth. Additional studies are warranted to explore this relationship further.

SUBMITTER: Zaigham M 

PROVIDER: S-EPMC7517619 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an observational study.

Zaigham Mehreen M   Hellström-Westas Lena L   Domellöf Magnus M   Andersson Ola O  

BMC pregnancy and childbirth 20200925 1


<h4>Background</h4>With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants.<h4>Methods</h4>We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their deve  ...[more]

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