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Impact of long-term glucose variability on coronary atherosclerosis progression in patients with type 2 diabetes: a 2.3 year follow-up study.


ABSTRACT: BACKGROUND:Glycemic variability (GV) confers a risk of cardiovascular events. In this study, we aimed to investigate whether long-term GV has an impact on coronary atherosclerosis progression in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 396 patients with T2DM who had coronary computed tomography angiography and laboratory data available at baseline and for follow-up evaluations [median 2.3 (1.8-3.1) years] were included. Fasting plasma glucose (FPG) was measured every 1-3 months, and HbA1c was measured quarterly. The coefficient of variation (CV) of HbA1c and FPG were calculated as measures of GV. Quantitative assessment of coronary plaques was performed by measuring the annual change and progression rate of total plaque volume (TPV). Significant progression was defined as annual TPV progression???15%. Multivariable regression analyses were used to assess the effects of GV on atherosclerosis progression. RESULTS:In the 396 patients, the annual change in TPV was 12.35?±?14.23 mm3, and annual progression rate was 13.36?±?12.69%. There were 143 (36.11%) patients with significant progression, and they had a significantly higher CV-HbA1c (P?

SUBMITTER: Li S 

PROVIDER: S-EPMC7517679 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Impact of long-term glucose variability on coronary atherosclerosis progression in patients with type 2 diabetes: a 2.3 year follow-up study.

Li Suhua S   Tang Xixiang X   Luo Yanting Y   Wu Bingyuan B   Huang Zhuoshan Z   Li Zexiong Z   Peng Long L   Ling Yesheng Y   Zhu Jieming J   Zhong Junlin J   Liu Jinlai J   Chen Yanming Y  

Cardiovascular diabetology 20200925 1


<h4>Background</h4>Glycemic variability (GV) confers a risk of cardiovascular events. In this study, we aimed to investigate whether long-term GV has an impact on coronary atherosclerosis progression in patients with type 2 diabetes mellitus (T2DM).<h4>Methods</h4>A total of 396 patients with T2DM who had coronary computed tomography angiography and laboratory data available at baseline and for follow-up evaluations [median 2.3 (1.8-3.1) years] were included. Fasting plasma glucose (FPG) was mea  ...[more]

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