A Review of PI3K Inhibitors in B-Cell Malignancies.
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ABSTRACT:
SUBMITTER: Cannon L
PROVIDER: S-EPMC7517780 | biostudies-literature | 2019 Sep-Oct
REPOSITORIES: biostudies-literature
Publications
A Review of PI3K Inhibitors in B-Cell Malignancies.
Cannon Laura L Academia Emmeline C EC Glode Ashley E AE
Journal of the advanced practitioner in oncology 20190901 7
The phosphoinositide 3-kinase (PI3K) pathway plays a primary role in cellular proliferation and metabolism. Inhibition of the PI3K pathway is an emerging area of drug development and cancer research. Idelalisib, copanlisib, and duvelisib are currently the only U.S. Food & Drug Administration-approved PI3K inhibitors available for use in hematologic malignancies. These PI3K inhibitors differ in their recommended indications, selectivity of PI3K isoforms, dosing, and potential toxicities. Several ...[more]
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