Ontology highlight
ABSTRACT:
SUBMITTER: Yan K
PROVIDER: S-EPMC7518254 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Yan Kai K Da Tian-Tian TT Bian Zhen-Hua ZH He Yi Y Liu Meng-Chu MC Liu Qing-Zhi QZ Long Jie J Li Liang L Gao Cai-Yue CY Yang Shu-Han SH Zhao Zhi-Bin ZB Lian Zhe-Xiong ZX
Cell death & disease 20200924 9
Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated that the transcription factor Forkhead Box Protein 1 (FoxO1) plays a pivotal role in regulating the function of macrophages, but the underlying mechanisms are still unclear. Here we identify FoxO1 as a regulator of macrophage function through metabolic reprogramming. Transcriptomic and proteomic analyses showed that the deficiency of FoxO1 re ...[more]