Ontology highlight
ABSTRACT:
SUBMITTER: Cross TJ
PROVIDER: S-EPMC7518256 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cross Thomas J TJ Takahashi Gemma R GR Diessner Elizabeth M EM Crosby Marquise G MG Farahmand Vesta V Zhuang Shannon S Butts Carter T CT Martin Rachel W RW
Biochemistry 20200924 39
The SARS-CoV-2 main protease (M<sup><i>pro</i></sup>) is essential to viral replication and cleaves highly specific substrate sequences, making it an obvious target for inhibitor design. However, as for any virus, SARS-CoV-2 is subject to constant neutral drift and selection pressure, with new M<sup><i>pro</i></sup> mutations arising over time. Identification and structural characterization of M<sup><i>pro</i></sup> variants is thus critical for robust inhibitor design. Here we report sequence a ...[more]