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ABSTRACT: Background
To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection.Study design
The hospital data of 235 patients infected with COVID-19 were analyzed.Results
Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage. Only 9.7% of patients older than 40 years who were vitamin D sufficient succumbed to the infection compared to 20% who had a circulating level of 25(OH)D< 30 ng/ml. The significant reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency also may help modulate the immune response possibly by reducing risk for cytokine storm in response to this viral infection.Conclusion
Therefore, it is recommended that improving vitamin D status in the general population and in particular hospitalized patients has a potential benefit in reducing the severity of morbidities and mortality associated with acquiring COVID-19.
SUBMITTER: Maghbooli Z
PROVIDER: S-EPMC7518605 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Maghbooli Zhila Z Sahraian Mohammad Ali MA Ebrahimi Mehdi M Pazoki Marzieh M Kafan Samira S Tabriz Hedieh Moradi HM Hadadi Azar A Montazeri Mahnaz M Nasiri Mehrad M Shirvani Arash A Holick Michael F MF
PloS one 20200925 9
<h4>Background</h4>To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection.<h4>Study design</h4>The hospital data of 235 patients infected with COVID-19 were analyzed.<h4>Results</h4>Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a signi ...[more]