ABSTRACT: Objective The study investigates psychological and social moderators of anxiety, depression, and personal stress in Saudi Arabian residents quarantined for COVID-19. Methods Data were collected from 200 participants quarantined in Saudi Arabia using the Emotion Regulation Scale (ERQ), Satisfaction With Life Scale (SWLS), Multidimensional Scale of Perceived Social Support (MSPSS), and the Hospital Anxiety and Depression Scale (HADS). Multiple regression analyses were carried out in SPSS. Results The results indicated that the overall prevalence of anxiety symptoms, depressive symptoms, and stress were 40.5%, 57.5%, and 55.5%, respectively. Cognitive reappraisal, satisfaction with life, and the social support of friends reduced depression and stress in quarantine. Additionally, females were more likely to be anxious but less likely to be depressed, while older residents generally experienced fewer anxiety and depression symptoms. Conclusion The findings indicate that residents in quarantine, especially younger people, experienced high levels of anxiety and depression. Therefore, continuous psychological monitoring and mental health support may need to be integrated into health care during pandemics. Highlights • COVID-19 has health, emotional, and social implications for individuals.• Being quarantined is a burden for individuals, so it is vital to understand and reduce its negative effects.• Emotional regulation processes are very effective in controlling anxiety, depression, and stress among quarantined residents.• Family support and friends support were crucial for fighting the stress levels of quarantined residents.