Mycobacterium tuberculosis progresses through two phases of latent infection in humans.
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ABSTRACT:
SUBMITTER: Colangeli R
PROVIDER: S-EPMC7519141 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Mycobacterium tuberculosis progresses through two phases of latent infection in humans.
Colangeli Roberto R Gupta Aditi A Vinhas Solange Alves SA Chippada Venkata Uma Deepthi UD Kim Soyeon S Grady Courtney C Jones-López Edward C EC Soteropoulos Patricia P Palaci Moisés M Marques-Rodrigues Patrícia P Salgame Padmini P Ellner Jerrold J JJ Dietze Reynaldo R Alland David D
Nature communications 20200925 1
Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new mutations in the M. tuberculosis genome decline dramatically after two years of latent infection ( ...[more]
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