PIK3R3 inhibits cell senescence through p53/p21 signaling.
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ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC7519147 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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PIK3R3 inhibits cell senescence through p53/p21 signaling.
Chen Qianzhi Q Sun Xuling X Luo Xuelai X Wang Jing J Hu Junbo J Feng Yongdong Y
Cell death & disease 20200924 9
Cellular senescence is a stress response of human cells that removes potentially harmful cells by initiating cell cycle arrest. Inducing senescence of tumor cells may be an effective tumor-inhibiting strategy. In this study we found that PIK3R3 could inhibit the cell senescence of colorectal cancer cells and promote cell proliferation through the p53/p21 signal pathway. PIK3R3 could bind to p53 and inhibit the binding of p53 to the p21 gene promoter region, and thus affecting the transcriptional ...[more]
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