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Clinical utility of genomic signatures in young breast cancer patients: a systematic review.


ABSTRACT: Risk stratification by genomic signatures has been shown to improve prognostication and guide treatment decisions among patients with hormone-sensitive breast cancer. However, their role in young women has not been fully elucidated. In this review, a systematic search was conducted for published articles and abstracts from major congresses that evaluated the use of genomic signatures in young breast cancer patients. A total of 71 studies were analyzed, including 561,188 patients of whom 27,748 (4.9%) were young. Women aged ?40 years were subjected to genomic testing at a similar rate to older women but had a higher proportion of intermediate- to high-risk tumors when classified by EndoPredict (p?=?0.04), MammaPrint (p?

SUBMITTER: Villarreal-Garza C 

PROVIDER: S-EPMC7519162 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Clinical utility of genomic signatures in young breast cancer patients: a systematic review.

Villarreal-Garza Cynthia C   Ferrigno Ana S AS   De la Garza-Ramos Cynthia C   Barragan-Carrillo Regina R   Lambertini Matteo M   Azim Hatem A HA  

NPJ breast cancer 20200925


Risk stratification by genomic signatures has been shown to improve prognostication and guide treatment decisions among patients with hormone-sensitive breast cancer. However, their role in young women has not been fully elucidated. In this review, a systematic search was conducted for published articles and abstracts from major congresses that evaluated the use of genomic signatures in young breast cancer patients. A total of 71 studies were analyzed, including 561,188 patients of whom 27,748 (  ...[more]

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