Ontology highlight
ABSTRACT:
SUBMITTER: George JM
PROVIDER: S-EPMC7519284 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
George Julia M JM Bell Zachary W ZW Condliffe Daniel D Dohrer Kirstin K Abaurrea Teresa T Spencer Karen K Leitão Albertine A Gahr Manfred M Hurd Paul J PJ Clayton David F DF
Proceedings of the National Academy of Sciences of the United States of America 20190722 38
Prolonged social isolation has negative effects on brain and behavior in humans and other social organisms, but neural mechanisms leading to these effects are not understood. Here we tested the hypothesis that even brief periods of social isolation can alter gene expression and DNA methylation in higher cognitive centers of the brain, focusing on the auditory/associative forebrain of the highly social zebra finch. Using RNA sequencing, we first identified genes that individually increase or decr ...[more]