Ontology highlight
ABSTRACT:
SUBMITTER: McEwen LM
PROVIDER: S-EPMC7519312 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
McEwen Lisa M LM O'Donnell Kieran J KJ McGill Megan G MG Edgar Rachel D RD Jones Meaghan J MJ MacIsaac Julia L JL Lin David Tse Shen DTS Ramadori Katia K Morin Alexander A Gladish Nicole N Garg Elika E Unternaehrer Eva E Pokhvisneva Irina I Karnani Neerja N Kee Michelle Z L MZL Klengel Torsten T Adler Nancy E NE Barr Ronald G RG Letourneau Nicole N Giesbrecht Gerald F GF Reynolds James N JN Czamara Darina D Armstrong Jeffrey M JM Essex Marilyn J MJ de Weerth Carolina C Beijers Roseriet R Tollenaar Marieke S MS Bradley Bekh B Jovanovic Tanja T Ressler Kerry J KJ Steiner Meir M Entringer Sonja S Wadhwa Pathik D PD Buss Claudia C Bush Nicole R NR Binder Elisabeth B EB Boyce W Thomas WT Meaney Michael J MJ Horvath Steve S Kobor Michael S MS
Proceedings of the National Academy of Sciences of the United States of America 20191014 38
The development of biological markers of aging has primarily focused on adult samples. Epigenetic clocks are a promising tool for measuring biological age that show impressive accuracy across most tissues and age ranges. In adults, deviations from the DNA methylation (DNAm) age prediction are correlated with several age-related phenotypes, such as mortality and frailty. In children, however, fewer such associations have been made, possibly because DNAm changes are more dynamic in pediatric popul ...[more]