Ontology highlight
ABSTRACT:
SUBMITTER: Xu B
PROVIDER: S-EPMC7519529 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Epigenetics & chromatin 20200925 1
<h4>Background</h4>UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate gene activation, but its molecular activities in developmental gene regulation remain unclear.<h4>Results</h4>We report that in human neural stem cells, UTX binding correlates with both promotion and suppression of gene expression. These activities enable UTX to modulate neural stem cell self-renewal, promote neurogenesis, and suppress glio ...[more]