Ontology highlight
ABSTRACT:
SUBMITTER: Chamoli M
PROVIDER: S-EPMC7519657 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chamoli Manish M Goyala Anita A Tabrez Syed Shamsh SS Siddiqui Atif Ahmed AA Singh Anupama A Antebi Adam A Lithgow Gordon J GJ Watts Jennifer L JL Mukhopadhyay Arnab A
Nature communications 20200925 1
The metabolic state of an organism instructs gene expression modalities, leading to changes in complex life history traits, such as longevity. Dietary restriction (DR), which positively affects health and life span across species, leads to metabolic reprogramming that enhances utilisation of fatty acids for energy generation. One direct consequence of this metabolic shift is the upregulation of cytoprotective (CyTP) genes categorized in the Gene Ontology (GO) term of "Xenobiotic Detoxification P ...[more]