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[Mechanism of Ferroptosis and Its Research Progress in Lung Cancer].

ABSTRACT: Ferroptosis is a recently recognized form of regulated cell death caused by an iron-dependent accumulation of lipid reactive species. However, little research on ferroptosis and lung cancer, one of the most common tumors, has been carried out. This paper tries to review the research progress of ferroptotic suppression and explain it from the different ways of ferroptosis occurrence. Furthermore, as inducing ferroptosis to treat cancer gets more attention, we introduce four kinds of ferroptosis-inducing compounds and new prospects for lung cancer therapy to provide new ideas for lung cancer treatment.

SUBMITTER: Wu J

PROVIDER: S-EPMC7519954 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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[Mechanism of Ferroptosis and Its Research Progress in Lung Cancer].

Wu Jinming J Ma Lifang L Wang Jiayi J Qiao Yongxia Y

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20200806 9

Ferroptosis is a recently recognized form of regulated cell death caused by an iron-dependent accumulation of lipid reactive species. However, little research on ferroptosis and lung cancer, one of the most common tumors, has been carried out. This paper tries to review the research progress of ferroptotic suppression and explain it from the different ways of ferroptosis occurrence. Furthermore, as inducing ferroptosis to treat cancer gets more attention, we introduce four kinds of ferroptosis-i ...[more]

PMID: 32758348

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