Unknown

Dataset Information

0

Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes.


ABSTRACT: BACKGROUND:Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-term prognostic utility of low-density lipoprotein triglyceride (LDL-TG) in real-world patients with prediabetes (Pre-DM) or diabetes mellitus (DM) and coronary artery disease (CAD) is currently not available. The aim of the present study was to evaluate the impact of LDL-TG on major adverse cardiovascular events (MACEs) in patients with stable CAD under different glucose metabolism status. METHODS:A total of 4381 patients with CAD were consecutively enrolled and plasma LDL-TG level was measured by an automated homogeneous assay. They were categorized according to both status of glucose metabolism [DM, Pre-DM, normal glycaemia regulation (NGR)] and tertiles of LDL-TG. All subjects were followed up for the occurrence of MACEs. RESULTS:During a median of 5.1 (interquartile range 3.9 to 5.9) years' follow-up, 507 (11.6%) MACEs occurred. Cubic spline models showed a significant association between LDL-TG and MACEs in DM and Pre-DM but not in NGR. When the combined effect of elevated LDL-TG and glucose disorders was considered for risk stratification, the medium tertile of LDL-TG plus DM, and the highest tertile of LDL-TG plus Pre-DM or plus DM subgroups were associated with significantly higher risk of MACEs after adjustment of confounders including triglyceride [hazard ratios (95% confidence intervals): 1.843 (1.149-2.955), 1.828 (1.165-2.867), 2.212 (1.396-3.507), all p?

SUBMITTER: Jin JL 

PROVIDER: S-EPMC7520976 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes.

Jin Jing-Lu JL   Zhang Hui-Wen HW   Cao Ye-Xuan YX   Liu Hui-Hui HH   Hua Qi Q   Li Yan-Fang YF   Zhang Yan Y   Guo Yuan-Lin YL   Wu Na-Qiong NQ   Zhu Cheng-Gang CG   Xu Rui-Xia RX   Gao Ying Y   Li Xiao-Lin XL   Cui Chuan-Jue CJ   Liu Geng G   Sun Jing J   Dong Qian Q   Santos Raul R   Li Jian-Jun JJ  

Cardiovascular diabetology 20200927 1


<h4>Background</h4>Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-term prognostic utility of low-density lipoprotein triglyceride (LDL-TG) in real-world patients with prediabetes (Pre-DM) or diabetes mellitus (DM) and coronary artery disease (CAD) is currently not available. The aim of the present study was to evaluate the impact of LDL-T  ...[more]

Similar Datasets

| S-EPMC7469882 | biostudies-literature
| S-EPMC3475437 | biostudies-literature
| S-EPMC6171908 | biostudies-literature
| S-EPMC4501252 | biostudies-literature
| S-EPMC8119857 | biostudies-literature
| S-EPMC6015304 | biostudies-literature
| S-EPMC8064770 | biostudies-literature
| S-EPMC7691041 | biostudies-literature
| S-EPMC8085268 | biostudies-literature
| S-EPMC4718229 | biostudies-literature