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Life course trajectories of cardiovascular risk: Impact on atherosclerotic and metabolic indicators.


ABSTRACT: BACKGROUND AND AIMS:In this analysis, we estimated population-level trajectory groups of life course cardiovascular risk to explore their impact on mid-life atherosclerotic and metabolic outcomes. METHODS:This prospective study followed n?=?1269 Bogalusa Heart participants, each with at least 4 study visits from childhood in 1973 through adulthood in 2016. We used discrete mixture modeling to determine trajectories of cardiovascular risk percentiles from childhood to adulthood. Outcomes included mid-life subclinical atherosclerotic measures [(carotid intima-media thickness (cIMT), pulse wave velocity (PWV)], metabolic indicators [(diabetes and body mass index (BMI)], and short physical performance battery (SPPB). RESULTS:Between the mean ages of 9.6-48.3 years, we estimated five distinct trajectory groups of life course cardiovascular risk (High-Low, High-High, Mid-Low, Low-Low, and Low-High). Adult metabolic and vascular outcomes were significantly determined by life course cardiovascular risk trajectory groups (all p?

SUBMITTER: Pollock BD 

PROVIDER: S-EPMC7521150 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Life course trajectories of cardiovascular risk: Impact on atherosclerotic and metabolic indicators.

Pollock Benjamin D BD   Stuchlik Patrick P   Harville Emily W EW   Mills Katherine T KT   Tang Wan W   Chen Wei W   Bazzano Lydia A LA  

Atherosclerosis 20181108


<h4>Background and aims</h4>In this analysis, we estimated population-level trajectory groups of life course cardiovascular risk to explore their impact on mid-life atherosclerotic and metabolic outcomes.<h4>Methods</h4>This prospective study followed n = 1269 Bogalusa Heart participants, each with at least 4 study visits from childhood in 1973 through adulthood in 2016. We used discrete mixture modeling to determine trajectories of cardiovascular risk percentiles from childhood to adulthood. Ou  ...[more]

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