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Sharp Wave-Ripples in Human Amygdala and Their Coordination with Hippocampus during NREM Sleep.

ABSTRACT: Cooperative interactions between the amygdala and hippocampus are widely regarded as critical for overnight emotional processing of waking experiences, but direct support from the human brain for such a dialog is absent. Using overnight intracranial recordings in 4 presurgical epilepsy patients (3 female), we discovered ripples within human amygdala during nonrapid eye movement (NREM) sleep, a brain state known to contribute to affective processing. Like hippocampal ripples, amygdala ripples are associated with sharp waves, linked to sleep spindles, and tend to co-occur with their hippocampal counterparts. Moreover, sharp waves and ripples are temporally linked across the 2 brain structures, with amygdala ripples occurring during hippocampal sharp waves and vice versa. Combined with further evidence of interregional sharp-wave and spindle synchronization, these findings offer a potential physiological substrate for the NREM-sleep-dependent consolidation and regulation of emotional experiences.

SUBMITTER: Cox R

PROVIDER: S-EPMC7521160 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Subiculum as a generator of sharp wave-ripples in the rodent hippocampus.

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