Ontology highlight
ABSTRACT:
SUBMITTER: Choe N
PROVIDER: S-EPMC7521311 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Choe Nakwon N Shin Sera S Joung Hosouk H Ryu Juhee J Kim Young-Kook YK Ahn Youngkeun Y Kook Hyun H Kwon Duk-Hwa DH
Journal of cellular and molecular medicine 20200811 18
Calcium deposition in vascular smooth muscle cells (VSMCs) is a form of ectopic ossification in blood vessels. It can result in rigidity of the vasculature and an increase in cardiac events. Here, we report that the microRNA miR-134-5p potentiates inorganic phosphate (Pi)-induced calcium deposition in VSMCs by inhibiting histone deacetylase 5 (HDAC5). Using miRNA microarray analysis of Pi-treated rat VSMCs, we first selected miR-134-5p for further evaluation. Quantitative RT-PCR confirmed that m ...[more]