Ontology highlight
ABSTRACT:
SUBMITTER: Wan R
PROVIDER: S-EPMC7521522 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wan Rongjun R Jiang Juan J Hu Chengping C Chen Xi X Chen Cen C Zhao Bingrong B Hu Xinyue X Zheng Zhiyuan Z Li Yuanyuan Y
Aging 20200805 17
Neutrophilic asthma (NA) is a distinct airway inflammation disease with prominent neutrophil infiltration. The role played by neutrophil extracellular traps (NETs) in NA, however, is quite unclear. This study was based on the hypothesis that NETs are responsible for the second neutrophil wave and therefore contribute significantly to inflammation. The proinflammatory effects of NETs were evaluated in vitro and in vivo. Formation of NETs and neutrophil swarming was seen in a mouse model of NA. Ad ...[more]