Ontology highlight
ABSTRACT:
SUBMITTER: Tsabar M
PROVIDER: S-EPMC7521664 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Tsabar Michael M Mock Caroline S CS Venkatachalam Veena V Reyes Jose J Karhohs Kyle W KW Oliver Trudy G TG Regev Aviv A Jambhekar Ashwini A Lahav Galit G
Cell reports 20200801 5
Cellular responses to stimuli can evolve over time, resulting in distinct early and late phases in response to a single signal. DNA damage induces a complex response that is largely orchestrated by the transcription factor p53, whose dynamics influence whether a damaged cell will arrest and repair the damage or will initiate cell death. How p53 responses and cellular outcomes evolve in the presence of continuous DNA damage remains unknown. Here, we have found that a subset of cells switches from ...[more]