Ontology highlight
ABSTRACT:
SUBMITTER: Reed JC
PROVIDER: S-EPMC7521722 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Reed James C JC Preston-Hurlburt Paula P Philbrick William W Betancur Gabriel G Korah Maria M Lucas Carrie C Herold Kevan C KC
PloS one 20200928 9
The receptor for advanced glycation endproducts (RAGE) is expressed in T cells after activation with antigen and is constitutively expressed in T cells from patients at-risk for and with type 1 diabetes mellitus (T1D). RAGE expression was associated with an activated T cell phenotype, leading us to examine whether RAGE is involved in T cell signaling. In primary CD4+ and CD8+ T cells from patients with T1D or healthy control subjects, RAGE- cells showed reduced phosphorylation of Erk. To study T ...[more]