Ontology highlight
ABSTRACT:
SUBMITTER: Bhaskar S
PROVIDER: S-EPMC7522125 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Bhaskar Smitha S Sheshadri Preethi P Joseph Joel P JP Potdar Chandrakanta C Prasanna Jyothi J Kumar Anujith A
iScience 20200915 10
Studies revealing molecular mechanisms underlying neural specification have majorly focused on the role played by different transcription factors, but less on non-nuclear components. Earlier, we reported mitochondrial superoxide dismutase (SOD2) to be essential for self-renewal and pluripotency of mouse embryonic stem cells (mESCs). In the present study, we found SOD2 to be specifically required for neural lineage, but not the meso- or endoderm specification. Temporally, SOD2 regulated early neu ...[more]