Ontology highlight
ABSTRACT: Objective
Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD.Methods
Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data.Results
Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs.Conclusions
Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD.
SUBMITTER: Jia C
PROVIDER: S-EPMC7522198 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Jia Cuicui C Ou Yangpan Y Chen Yunhui Y Li Ping P Lv Dan D Yang Ru R Zhong Zhaoxi Z Sun Lei L Wang Yuhua Y Zhang Guangfeng G Guo Hong H Sun Zhenghai Z Wang Wei W Wang Yefu Y Wang Xiaoping X Guo Wenbin W
Frontiers in psychiatry 20200915
<h4>Objective</h4>Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD.<h4>Methods</h4>Forty medication-free patients with OCD and ...[more]