Erythrocyte ?-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study.
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ABSTRACT: OBJECTIVES:Evidence about ?-3 polyunsaturated fatty acids (?-3 PUFAs) and oral cancer risk were limited. We aimed to evaluate the association of erythrocyte ?-3 PUFAs with the risk of oral cancer in a population from China. METHODS:Erythrocyte ?-3 PUFAs of 236 oral cancer patients and 300 controls were determined by gas chromatography. Restricted cubic spline and logistic regression were used to analyze the association between erythrocyte ?-3 PUFAs and oral cancer risk. The crude and adjusted OR with 95% CI was calculated. Stratification analysis was performed to explore the potential interaction between ?-3 PUFAs and other traditional risk factors such as smoking and drinking. RESULTS:Eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA) and ?-3 index were negatively but non-linearly related to risk of oral cancer as observed by restricted cubic spline. The adjusted OR of EPA, DHA, and ?-3 index were 0.52 (95% CI: 0.35-0.76), 0.19 (95% CI: 0.08-0.44), 0.20 (95% CI: 0.09-0.44), respectively. Stratification analysis showed that the adverse correlation between EPA and oral cancer was only significant in the non-smoking group, while the adverse correlation of ?-linolenic acid (ALA), EPA, and DHA were only significant in the non-drinking group. General multiplicative interactions were observed between ?-3 PUFAs and smoking or drinking. CONCLUSIONS:Adverse but non-linear associations were observed between erythrocyte EPA, DHA, ?-3 index, and oral cancer risk. Additionally, there were multiplicative interactions between ?-3 PUFAs and other behavior factors such as smoking and drinking. The protective effect of ?-3 PUFAs maybe more significant in the non-smoking or non-drinking population.
SUBMITTER: Chen Q
PROVIDER: S-EPMC7522234 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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