Dataset Information

Erythrocyte ?-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study.

ABSTRACT: OBJECTIVES:Evidence about ?-3 polyunsaturated fatty acids (?-3 PUFAs) and oral cancer risk were limited. We aimed to evaluate the association of erythrocyte ?-3 PUFAs with the risk of oral cancer in a population from China. METHODS:Erythrocyte ?-3 PUFAs of 236 oral cancer patients and 300 controls were determined by gas chromatography. Restricted cubic spline and logistic regression were used to analyze the association between erythrocyte ?-3 PUFAs and oral cancer risk. The crude and adjusted OR with 95% CI was calculated. Stratification analysis was performed to explore the potential interaction between ?-3 PUFAs and other traditional risk factors such as smoking and drinking. RESULTS:Eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA) and ?-3 index were negatively but non-linearly related to risk of oral cancer as observed by restricted cubic spline. The adjusted OR of EPA, DHA, and ?-3 index were 0.52 (95% CI: 0.35-0.76), 0.19 (95% CI: 0.08-0.44), 0.20 (95% CI: 0.09-0.44), respectively. Stratification analysis showed that the adverse correlation between EPA and oral cancer was only significant in the non-smoking group, while the adverse correlation of ?-linolenic acid (ALA), EPA, and DHA were only significant in the non-drinking group. General multiplicative interactions were observed between ?-3 PUFAs and smoking or drinking. CONCLUSIONS:Adverse but non-linear associations were observed between erythrocyte EPA, DHA, ?-3 index, and oral cancer risk. Additionally, there were multiplicative interactions between ?-3 PUFAs and other behavior factors such as smoking and drinking. The protective effect of ?-3 PUFAs maybe more significant in the non-smoking or non-drinking population.

SUBMITTER: Chen Q

PROVIDER: S-EPMC7522234 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Erythrocyte ω-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study.

Chen Qing Q Wang Jing J Wang Jing J Lin Jing J Chen Lin L Lin Li-Song LS Pan Li-Zhen LZ Shi Bin B Qiu Yu Y Zheng Xiao-Yan XY Chen Fa F He Bao-Chang BC Liu Feng-Qiong FQ

Nutrition & diabetes 20200928 1

<h4>Objectives</h4>Evidence about ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and oral cancer risk were limited. We aimed to evaluate the association of erythrocyte ω-3 PUFAs with the risk of oral cancer in a population from China.<h4>Methods</h4>Erythrocyte ω-3 PUFAs of 236 oral cancer patients and 300 controls were determined by gas chromatography. Restricted cubic spline and logistic regression were used to analyze the association between erythrocyte ω-3 PUFAs and oral cancer risk. The crude ...[more]

PMID: 32989214

Similar Datasets

Project description:BackgroundOptimal ω-6/ω-3 polyunsaturated fatty acids ratio (PUFAR) is reported to exert protective effects against chronic diseases. However, data on PUFAR and diabetic retinopathy (DR) remains scarce. We aimed to thoroughly quantify whether and how PUFAR was related to DR as well as its role in DR detection.MethodsThis two-centre case-control study was conducted from August 2017 to June 2018 in China, participants were matched using a propensity score matching algorithm. We adopted multivariable logistic regression models and restricted cubic spline analyses to estimate the independent association of PUFAR with DR, adjusting for confounders identified using a directed acyclic graph. The value of PUFAR as a biomarker for DR identification was further evaluated by receiver operating characteristic analyses and Hosmer-Lemeshow tests.FindingsAn apparent negative relationship between PUFAR and DR was observed. Adjusted odds of DR decreased by 79% (OR: 0·21, 95% CI: 0·10-0·40) with an interquartile range increase in PUFAR. Similar results were also obtained in tertile analysis. As compared to those in the 1st tertile of PUFAR, the adjusted odds of DR decreased by 76% (OR: 0·24, 95% CI: 0·08-0·66) and 93% (OR: 0·07, 95% CI: 0·03-0·22) for subjects in the 2nd and 3rd tertiles, respectively. Good calibration and discrimination of the PUFAR associated predictive model were detected and PUFAR = 35 would be an ideal cut-off value for DR identification.InterpretationOur results suggest that serum PUAFR is inversely associated with DR. Although PUFAR-alteration is not observed amongst different stages of DR, it can serve as an ideal biomarker in distinguishing patients with DR from those without DR.FundingThis study was funded by Natural Science Foundation of Zhejiang Province, Zhejiang Basic Public Welfare Research Project, the Major Project of the Eye Hospital of Wenzhou Medical University, and the Academician's Science and Technology Innovation Program in Zhejiang province. Part of this work was also funded by the National Nature Science Foundation of China, and Research Project for College Students in Wenzhou Medical University.

Dataset Information

Erythrocyte ?-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study.

Publications

Erythrocyte ω-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets