Ontology highlight
ABSTRACT:
SUBMITTER: Glenthoj A
PROVIDER: S-EPMC7522531 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Glenthøj Andreas A Sharfo Alaa A Brieghel Christian C Nardo-Marino Amina A Birgens Henrik H Petersen Jesper Brix JB
Frontiers in physiology 20200915
Hereditary spherocytosis (HS) is a common anemia caused by germline mutations in red blood cell cytoskeleton proteins. The flow cytometry-based eosin-5'-maleimide (EMA) binding test is most frequently employed for reliable diagnostics. To perform this test, a number of healthy and ideally also age-matched controls are required, which can be challenging and complicates interlaboratory comparisons. To overcome this limitation, we modified the EMA binding test by replacing healthy controls with com ...[more]